Sofosbuvir 400 mg And 100mg Velpatasvir Tablets

About Sofosbuvir 400 mg And 100mg Velpatasvir Tablets

1 Fixeddose oral tablet combining sofosbuvir NS5B polymerase inhibitor and velpatasvir NS5A inhibitor for hepatitisC treatment 

2 Indicated to treat chronic hepatitisC virus genotypes1 through6 in adults and in children aged 6years or 17kg with or without cirrhosis in decompensated cirrhosis used with ribavirin 

3 Typical regimen one tablet once daily with or without food usually for 12weeks 

4 Cure rates generally 90 across all major genotypes including those coinfected with HIV 

5 Common side effects 10 include fatigue headache nausea diarrhea and insomnia Wikipedia1 RxList4 Drugscom3

6 Less frequent effects rash irritability back pain dizziness anemia especially when combined with ribavirin Wikipedia5 Drugscom3

7 Serious warning risk of hepatitisB virus reactivation in patients with current or prior HBV infectionmonitor and screen before use 

8 Another serious risk symptomatic bradycardia if coadministered with amiodaronepotentially fatal or requiring pacemaker Drugscom3 RxList6

9 Numerous drug interactions contraindicated with strong inducers of CYP3A4 CYP2B6 CYP2C8 or Pgp eg rifampin St Johns Wort carbamazepine which reduce efficacy 

10 Velpatasvir inhibits several drug transporters OATP1B11B32B1 Pgp BCRP raising levels of coadministered drugs like statins or anticoagulantsdose adjustments or monitoring needed 

11 Pregnancybirth control when used with ribavirin causes severe birth defects effective contraception required during and for six months after treatment 

12 Allergic reactions may occur stop treatment if hives facial o throat swelling or breathing difficulty develop 

13 Monitor liver function and labs eg hemoglobin blood glucose in diabetics warfarin INR during therapy