Midodrine 5mg

Product Description

Here is a revised summary in approximately 10“15 lines as requested, all supported by authoritative sources:

Midodrine hydrochloride tablets are indicated for symptomatic orthostatic hypotension”that is, clinically significant drops in blood pressure when standing that cause dizziness, fainting, or impaired quality of life despite non‘pharmacologic measures such as fluids or compression stockings ([MedLibrary.org1]). They are a prodrug, producing the active metabolite desglymidodrine, a selective ‘adrenergic agonist that constricts blood vessels to elevate standing and sitting systolic blood pressure by \15“30mmHg within \1hour of a 10mg dose ([Drugs.com2]). The usual adult dose is 10mg orally three times daily during waking hours, at \3“4‘hour intervals, with the last dose given at least 4hours before bedtime (ideally not after 6p.m.) to minimize supine hypertension ([NDC List3]). In patients with renal impairment”e.g. creatinine clearance below \90mL/min”therapy should be initiated at 2.5mg three times daily with cautious titration ([NDC List3]). Midodrine is contraindicated in patients with severe organic heart disease, acute kidney disease, urinary retention, pheochromocytoma, thyrotoxicosis, and persistent/excessive supine hypertension (such as baseline supine systolic BP >180mmHg) ([MedLibrary.org1]). Other notable contraindications and precautions include severe vascular disease, proliferative diabetic retinopathy, narrow-angle glaucoma, and known hypersensitivity to midodrine or excipients ([Medicines.org.uk4]). Routine monitoring of supine, sitting, and standing blood pressures is required, and therapy should be discontinued if supine blood pressure increases excessively or if no symptomatic benefit is evident after initiation ([Drugs.com5]). Caution is also advised in patients with diabetes, hepatic impairment, concomitant use of vasoconstrictor or negative chronotropic agents (e.g. beta-blockers, digoxin), and conditions that predispose to bradycardia or urinary retention .